Organic Chaste Berry Tree Fruit Powder
Also known as: Chasteberry, Chaste Tree, Monk's Pepper, *Vitex agnus-castus*
Overview
Chasteberry (*Vitex agnus-castus*) is a plant native to the Mediterranean region, renowned for its fruit which has been incorporated into traditional medicine for centuries. Rich in bioactive compounds such as flavonoids, alkaloids, and iridoids, chasteberry is primarily recognized for its ability to alleviate symptoms associated with premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), cyclical breast discomfort, and menstrual irregularities. Its normalizing effects on the menstrual cycle are attributed to nonsteroidal progestins that interact with hormone receptors. While research demonstrates moderate support through randomized controlled trials (RCTs) and meta-analyses, there remains a need for more rigorous studies to fully establish its efficacy and optimal dosing. The evidence quality is mixed due to heterogeneity and potential biases in available studies.
Benefits
Chasteberry is most notably effective in reducing PMS symptoms, with meta-analytic findings indicating that women using chasteberry are 2.57 times more likely to see symptom remission compared to placebo. The pooled effect size of chasteberry across placebo-controlled trials shows significant benefits, although the findings are tempered by high heterogeneity and bias risk. Additionally, chasteberry may aid in alleviating cyclical breast discomfort, though evidence for its efficacy in menstrual irregularities and infertility is less robust. Women aged 20-40, especially those with normal ovarian function, appear to benefit the most from its use for PMS and breast discomfort. It is suggested that noticeable benefits typically emerge within a few menstrual cycles.
How it works
Chasteberry’s mechanism involves modulation of the dopaminergic system, primarily through the inhibition of pituitary prolactin release which is elevated during the premenstrual cycle. Additionally, it exhibits opioidergic effects, activating mu- and delta-opioid receptors due to flavonoid casticin. This herb interacts with the endocrine system, specifically influencing the hypothalamic-pituitary axis, affecting hormonal regulation and homeostasis in reproductive health.
Side effects
Chasteberry is generally well-tolerated; however, common side effects reported in clinical studies include nausea, headaches, gastrointestinal disturbances, menstrual disorders, acne, and skin reactions such as itching and redness. Less frequently, dizziness and dry mouth may occur. There are no well-documented rare side effects, but caution is advised regarding potential interactions with medications, notably dopamine agonists or antagonists. Pregnant or breastfeeding women should exercise caution when using chasteberry due to limited safety data, and those with hormone-sensitive conditions should also take precautions. Overall, while chasteberry is considered safe for many, consulting with healthcare providers, especially for special populations, is advisable.
Dosage
Typical dosage ranges for chasteberry vary from 500 mg to 1000 mg per day of a standardized extract, although the minimum effective dose is not clearly established. Doses above 1000 mg per day have not been commonly studied or recommended. The supplement is usually taken once daily, with effects observable over several menstrual cycles. Standardized extracts containing specific bioactive compounds like casticin are preferred due to the variability in active ingredient content. While the influence of food on absorption is not thoroughly detailed, it is suggested that consumption timing and form may impact bioavailability.
FAQs
How long does it take to see benefits?
Benefits typically manifest within a few menstrual cycles.
Can it be used during pregnancy or breastfeeding?
It should be used with caution and under medical supervision.
Are there any interactions with other medications?
Caution is advised with dopamine agonists or antagonists.
What are the common side effects?
Common side effects include nausea, headaches, and gastrointestinal disturbances.
Are there any contraindications?
Use with caution in women with hormone-sensitive conditions.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/31780016/ – This meta-analysis evaluated the impact of chasteberry on PMS symptoms, finding a significant increase in remission rates for those using the supplement compared to placebo groups. Methodological limitations highlighted the need for further trials.
- https://www.mskcc.org/cancer-care/integrative-medicine/herbs/chasteberry – The Memorial Sloan Kettering Cancer Center provides insights on chasteberry's applications in managing PMS and menstrual disorders, summarizing its potential benefits and caution in various populations.
- https://pubmed.ncbi.nlm.nih.gov/16156340/ – This systematic review and meta-analysis assessed chasteberry's efficacy in treating PMS and PMDD, revealing a large pooled effect but also underscoring concerns regarding study quality and heterogeneity.
- https://womensmentalhealth.org/posts/chasteberry-for-pms-and-pmdd/ – A review of clinical trials highlighted chasteberry's positive effects on PMS and related conditions, while stressing the variability in study design and quality of evidence.
- https://www.cambridge.org/core/journals/european-psychiatry/article/treatment-of-premenstrual-syndrome-with-preparations-of-vitex-agnus-castus-chasteberry-a-systematic-review-and-metaanalysis/C11517A1EF3D285632F73F23E32F0FE2 – A systematic review explored the treatments for premenstrual syndrome using chasteberry, finding evidence of efficacy while noting the challenges of inconsistent study outcomes and methodologies.
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