Oregano Leaf Supercritical Co2 Extract
Also known as: Origanum vulgare extract, Oregano oil, Oregano supercritical CO2 extract, Oregano Leaf Extract
Overview
Oregano leaf extract is obtained from the leaves of the *Origanum vulgare* plant, celebrated for its diverse culinary and medicinal applications. This extract is rich in bioactive compounds, particularly carvacrol and thymol, which contribute to its notable antimicrobial, anti-inflammatory, and antioxidant properties. The supercritical CO2 extraction method effectively preserves these sensitive compounds, ensuring a high-quality product. Published research, including multiple in vitro studies and some animal trials, has indicated potential health benefits. However, further clinical trials involving human subjects are required to establish more conclusive evidence and guidelines regarding its efficacy and safety in various applications.
Benefits
Oregano leaf extract demonstrates several evidence-supported benefits. Its potent antimicrobial activity, particularly against *Candida albicans*, is largely attributed to carvacrol, as indicated by numerous high-quality in vitro studies. Additionally, the extract exhibits anti-inflammatory properties, relevant for individuals at risk of atherosclerosis, by modulating cytokine production. Its antioxidant effects have been noted, though further human-centric studies are necessary for precise quantification. In livestock, oregano extracts have been shown to enhance digestive health by improving ruminal fermentation and reducing methane production, benefiting animal nutrition. These findings illustrate significant potential, although they are supported by limited human trial data.
How it works
The antimicrobial effects of oregano leaf extract are primarily due to carvacrol, which disrupts microbial cell membranes, resulting in cellular leakage and ultimately, death of the pathogens. Its anti-inflammatory action is associated with the modulation of cytokine production, reducing levels of pro-inflammatory cytokines and increasing anti-inflammatory ones like IL-10. Furthermore, in animal studies, oregano leaf extract aids in optimizing digestive fermentation processes, further contributing to overall health.
Side effects
Oregano leaf extract is generally considered safe when consumed in moderation. However, excessive intake, especially at concentrations exceeding 30 microg/mL, may cause cytotoxicity, negatively impacting cell viability in vitro. While common adverse effects (>5%) have not been thoroughly studied in humans, potential issues may include gastrointestinal discomfort and allergic reactions, particularly in individuals sensitive to Lamiaceae family plants. Less common side effects (1-5%) might involve mild allergic responses, while rare side effects (<1%) are not documented in current literature. Special caution should be exercised by pregnant or breastfeeding women, elderly individuals, and those with specific medical conditions, as well as in conjunction with medications that affect the immune or digestive systems.
Dosage
The effective dosage of oregano leaf extract for human use has not been clearly established, with most existing studies utilizing concentrations exceeding 30 microg/mL in in vitro scenarios. Clinical trials are necessary to pinpoint optimal dosage ranges. To enhance absorption, it is advisable to take oregano extracts with meals. Safety guidelines recommend a threshold of 30 microg/mL to avoid risks of cytotoxicity. Notably, supercritical CO2 extracts may offer higher bioavailability than traditional extracts, potentially allowing for lower dosing to achieve effective results.
FAQs
Are oregano leaf extracts safe to use?
Oregano leaf extracts are generally safe, but high concentrations can cause cytotoxicity. Caution is advised, especially for vulnerable populations.
When should I take oregano leaf extract?
There is no specific timing recommended, but it may enhance absorption when taken with meals.
What effects can I expect from using oregano leaf extracts?
You can expect antimicrobial and anti-inflammatory benefits; however, the extent of these effects in humans requires further study.
Can oregano leaf extracts replace medications?
No, oregano leaf extracts should be considered complementary to medical therapies rather than substitutes.