Myrica cerifera 6X
Also known as: Myrica cerifera, Bayberry, Wax Myrtle
Overview
Myrica cerifera, commonly known as Bayberry or Wax Myrtle, is a plant native to North America. Its bark has been traditionally used in herbal medicine for its potential anti-inflammatory, antioxidant, and anti-cancer properties. The plant contains bioactive compounds like myricanone, which has been studied for its apoptosis-promoting ability, particularly in liver cancer cell lines. While traditionally used for various ailments, the current body of evidence supporting its benefits is primarily preclinical, with limited human clinical trials available. Most research consists of in vitro and animal studies, highlighting the need for more rigorous human trials to validate its efficacy and safety. Myrica cerifera supplements are available in various forms, often as bark extracts.
Benefits
Myricanone, a key compound in Myrica cerifera, has demonstrated potential in inducing apoptosis in cancer cells, specifically in liver cancer cell lines like HepG2, according to in vitro studies. This effect is primarily observed through mechanisms involving reactive oxygen species (ROS) generation and mitochondrial membrane depolarization. Additionally, Myrica cerifera may offer antioxidant and anti-inflammatory effects, although these are less substantiated by human studies. While potentially beneficial for individuals with liver conditions or at risk of liver cancer, the evidence remains preliminary, and more research is needed to confirm these benefits and determine appropriate dosages and long-term effects. The effect sizes and clinical significance in humans are not well-documented due to the lack of extensive human trials.
How it works
Myricanone, a bioactive compound in Myrica cerifera, induces apoptosis through reactive oxygen species (ROS) generation, mitochondrial membrane depolarization, and activation of caspase cascades. It may interact with cellular signaling pathways, including NF-κB and STAT3 inhibition. Research indicates that myricanone may target DNA polymerase α and I, as well as RNA polymerase. However, the absorption and bioavailability of Myrica cerifera compounds in humans are not well-studied, limiting a complete understanding of its mechanism of action in vivo. Further research is needed to elucidate the precise pathways and interactions within the human body.
Side effects
The safety profile of Myrica cerifera supplements is not extensively documented, primarily due to the limited number of human clinical trials. While generally considered safe when used traditionally, specific safety data for Myrica cerifera supplements are lacking. Common, uncommon, and rare side effects are not well-documented. Potential drug interactions may occur with medications affecting liver function or metabolism. Due to the lack of safety data, Myrica cerifera is contraindicated during pregnancy and breastfeeding. Caution is advised for individuals with pre-existing liver conditions or those taking medications metabolized by the liver. It is essential to consult with a healthcare professional before using Myrica cerifera supplements, especially if you have underlying health conditions or are taking other medications.
Dosage
Due to the limited human clinical trials, a minimum effective dose, optimal dosage ranges, and maximum safe dose for Myrica cerifera have not been established. Timing considerations for administration are also not well-defined. Traditional use involves bark extracts, but specific form-specific recommendations are lacking. Absorption factors and required cofactors are not well-studied. Given the lack of comprehensive data, it is crucial to approach Myrica cerifera supplementation with caution and under the guidance of a healthcare professional. Until further research is available, specific dosage recommendations cannot be provided.
FAQs
Is Myrica cerifera safe to use?
Safety data is limited, so use with caution. It is contraindicated in pregnancy and breastfeeding. Consult a healthcare professional before use, especially if you have underlying health conditions or are taking medications.
What are the expected benefits of Myrica cerifera?
Potential benefits include liver health and cancer prevention, but more research is needed. Most evidence is from preclinical studies, so human benefits are not yet well-established.
How should I take Myrica cerifera?
Due to a lack of human clinical trials, there are no established guidelines for timing or administration. Traditional use involves bark extracts, but specific recommendations are lacking. Consult a healthcare professional for guidance.
Are there any misconceptions about Myrica cerifera?
A common misconception is the belief in established human health benefits without sufficient evidence. Most research is preclinical, and more human trials are needed to validate its efficacy and safety.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/23972241/ – This in vitro study demonstrated that myricanone induces apoptosis in HepG2 liver cancer cells through ROS generation and mitochondrial membrane depolarization. The findings suggest a potential anti-cancer mechanism, but the study's limitations include its in vitro nature and the absence of human data, warranting further investigation.
- https://www.mdpi.com/1420-3049/25/24/6052 – This review highlights the potential health benefits of compounds from Myrica species, including anti-inflammatory and antioxidant effects. However, the review primarily focuses on in vitro and animal studies, indicating a need for more human clinical trials to confirm these effects in humans.
- https://nclinnovations.org/covid19/wp-content/uploads/2020/06/TFORD-HerbalBriefs-09-Myrica-cerifera-v1.pdf – This brief on Myrica cerifera notes its traditional use but highlights the lack of clinical trials. The absence of systematic reviews or meta-analyses underscores the need for more rigorous research to establish the efficacy and safety of Myrica cerifera supplements.
- https://www.science.gov/topicpages/m/myrica+rubra+fruit.html – This link discusses Myrica rubra fruit, which is related to Myrica cerifera. While not directly about Myrica cerifera, it provides context on the Myrica genus and its potential health benefits, indicating a broader interest in the medicinal properties of Myrica species.
- https://www.alk.net/us/sites/www.alk.us/files/2024-01/2024_alk_product_catalog.pdf – This is a product catalog that may contain information about Myrica cerifera as an ingredient in certain products. It could provide insights into how the ingredient is being used commercially, but it is not a primary research source.
