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Dry Cold Pressed Borage Seed Oil

Also known as: Borage Oil, Borage Seed Oil, Borago Oil, Starflower Oil, Borago officinalis (Borage Seed Oil)

Overview

Borage seed oil is derived from the seeds of the Borago officinalis plant, renowned for its high concentration of gamma-linolenic acid (GLA), an essential omega-6 fatty acid. GLA is critical for maintaining cellular health and has significant anti-inflammatory and antioxidant properties. Borage seed oil is utilized primarily for therapeutic purposes, particularly in managing conditions such as arthritis, atopic dermatitis, and respiratory disorders. Research has shown its effectiveness in improving skin hydration and reducing inflammation, making it valuable for diverse populations, including pediatric and critical care patients. Despite its promising benefits, the evidence for its efficacy varies across conditions, necessitating further research to ascertain safety and effectiveness across different demographics.

Benefits

Borage seed oil offers several health benefits supported by scientific research. It has been shown to reduce inflammation by decreasing levels of inflammatory cytokines such as TNF-α and IL-6, particularly in studies involving COVID-19 patients. Clinical trials demonstrate significant improvements in skin health, notably in children with atopic dermatitis where it reduces transepidermal water loss (TEWL) and enhances hydration. Additionally, it has potential benefits for respiratory health, particularly in patients with acute respiratory distress syndrome (ARDS), when used in conjunction with EPA supplementation. While there is acknowledgment of its potential to alleviate arthritis-related pain, further studies are needed to confirm this benefit. Clinical improvements are often observed within days to weeks, indicating its potential as a valuable adjunct therapy.

How it works

The therapeutic effects of borage seed oil mainly stem from GLA's metabolism into active compounds like dihomo-γ-linolenic acid (DHLA), arachidonic acid (AA), and prostaglandin E1 (PGE1). These metabolites play crucial roles in suppressing inflammation and modulating immune responses, particularly by inhibiting the synthesis of pro-inflammatory cytokines. Furthermore, borage oil contributes to enhanced skin barrier function, leading to improved hydration and lower transepidermal water loss. Its absorption and bioavailability can be enhanced when taken with nutrients such as vitamin C, zinc, and magnesium, which support its metabolic pathways.

Side effects

Borage seed oil is generally considered safe when used in accordance with guidelines, especially those devoid of harmful pyrrolizidine alkaloids (PAs). Adverse side effects occur in less than 5% of users with PA-free products, but some rare effects may include liver damage and an increased risk of cancer linked to non-PA-free forms. Caution should be exercised with potential drug interactions, especially with CYP3A4 inducers and anticoagulants, which may elevate toxicity and bleeding risks, respectively. Pregnant and breastfeeding women are advised to consult healthcare professionals before use. Overall, following safety guidelines enhances its favorable safety profile.

Dosage

The recommended dosage of borage seed oil typically ranges from 1 to 2 grams daily, delivering approximately 20 to 40 mg of gamma-linolenic acid (GLA) per day. For inflammatory conditions, research suggests optimal dosages between 1.4 to 2.8 grams per day. Although a maximum safe dose has not been definitively established, higher dosages should be approached with caution due to potential adverse effects and interactions with medications. Oral formulations are recommended for systemic benefits, whereas topical applications are suitable for localized skin issues. Additionally, intake of vitamin C, zinc, and magnesium can enhance the absorption and effectiveness of borage seed oil.