Chinese Salvia Root Extract
Also known as: Chinese Salvia, Danshen, Red Sage, *Salvia miltiorrhiza*
Overview
*Salvia miltiorrhiza*, known as Danshen, is a species of flowering plant in the mint family that is native to China and other parts of Asia. Commonly employed in traditional Chinese medicine (TCM), this herbal extract is renowned for its cardiovascular protections and its role in enhancing renal function. Its bioactive constituents, such as salvianolic acids and tanshinones, contribute to its medicinal properties. Historically, Danshen is used to mitigate cardiovascular disorders, chronic kidney disease (CKD), and even conditions like endometriosis. Based on a body of emerging research, various clinical trials and studies substantiate its efficacy, leading to an acknowledgment of *Salvia miltiorrhiza* as a beneficial agent within the TCM framework, reflected through moderate to high-quality evidence across multiple clinical contexts.
Benefits
The benefits of *Salvia miltiorrhiza* are well-documented. For CKD, a meta-analysis encompassing 32 studies found significant improvements in kidney function indicators, including a marked reduction in serum creatinine and blood urea nitrogen levels ([1][5]). Another robust benefit is observed in cardiovascular health, where *Salvia miltiorrhiza* has been shown to improve cardiac function and decrease blood lipid levels in numerous clinical trials ([2]). Additionally, use in conjunction with GnRH agonists has evidenced reduced recurrence of endometriosis and improved pregnancy outcomes ([3]). not only are these benefits significant, but they tend to persist with prolonged use, showcasing the herbal extract’s depth of impact on chronic health conditions.
How it works
*Salvia miltiorrhiza* operates through several biological pathways, notably featuring antioxidant and anti-inflammatory effects. Key compounds such as salvianolic acids and tanshinones enhance endothelial function by influencing pathways like eNOS, promoting vasodilation, while simultaneously modulating inflammatory responses via NF-κB pathways. This dual action benefits the cardiovascular system through better blood flow and aids renal function by decreasing proteinuria and improving overall kidney function ([1][2]).
Side effects
Generally, *Salvia miltiorrhiza* is considered safe; however, common side effects above 5% include gastrointestinal disturbances such as nausea and diarrhea, which are comparable to control groups in studies ([1][3]). Less frequent (1-5%) adverse reactions lack detailed reports but are not typically severe. Rarely (<1%), allergic reactions have been noted. There are cautions against potential drug interactions with anticoagulants and cardiovascular medications due to its blood-thinning effects. Patient considerations include caution for individuals with bleeding disorders and pregnant or breastfeeding women, who should seek medical advice prior to use due to insufficient safety data.
Dosage
The effective dosing for *Salvia miltiorrhiza* varies based on the health condition being addressed. For chronic kidney disease, optimal dosages typically range from 1.5 to 2.5 grams per day, while cardiovascular applications may require 1-3 grams daily. The minimum effective dose is usually found to be around 1-3 grams of dried root daily. Administration timing is important, as taking it with meals can mitigate gastrointestinal side effects. Various forms are available, including capsules and decoctions, with the latter potentially offering enhanced bioavailability of the herb's active constituents. Safety thresholds remain undefined, although exceeding 3 grams may not have extensive research backing.
FAQs
Is *Salvia miltiorrhiza* safe to use?
Generally, *Salvia miltiorrhiza* is safe, but watch for medication interactions, especially with anticoagulants.
When should I take *Salvia miltiorrhiza*?
It’s best taken with meals to diminish the chance of gastrointestinal issues.
What results can I expect from *Salvia miltiorrhiza*?
Users may observe improvements in kidney health and cardiovascular benefits over months to years.
Can *Salvia miltiorrhiza* replace my medications?
*Salvia miltiorrhiza* should complement, not replace, conventional treatments for medical conditions.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/35747383/ – This meta-analysis highlighted significant improvements in kidney function following treatment with *Salvia miltiorrhiza*, with substantial sample size and evidence supporting its efficacy for CKD.
- https://pubmed.ncbi.nlm.nih.gov/27748194/ – The review of clinical trials established various pharmacological actions of *Salvia miltiorrhiza* in treating cardiovascular diseases, encompassing different mechanisms including lipid modulation and cardiac performance enhancement.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.831850/full – This systematic review illustrated reduced recurrence rates of endometriosis when *Salvia miltiorrhiza* was combined with conventional treatments, enhancing clinical outcomes in postoperative patients.
- https://www.science.gov/topicpages/n/natural+medicine+research – This source compiles various studies on natural medicine, emphasizing the role of *Salvia miltiorrhiza* in traditional and contemporary herbal applications.
- https://onlinelibrary.wiley.com/doi/10.1155/2022/2117433 – The research supports *Salvia miltiorrhiza* as beneficial for cardiovascular issues, summarizing findings from multiple clinical trials conducted since 2000.
Supplements Containing Chinese Salvia Root Extract

Arjuna CardioComfort 460 mg
Planetary Herbals

Cinnamon Glucose Balance 910 mg
Planetary Herbals

Cinnamon Glucose Balance 910 mg
Planetary Herbals

Cinnamon Glucose Balance 910 mg
Planetary Herbals

Full Spectrum Salvia 1020 mg
Planetary Herbals

Myelin Sheath Support 820 mg
Planetary Herbals

Myelin Sheath Support 820 mg
Planetary Herbals

Myelin Sheath Support 820 mg
Planetary Herbals

Blood Pressure Response
Source Naturals

Blood Pressure Response
Source Naturals

Blood Pressure Response
Source Naturals

Blood Pressure Response
Source Naturals
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